effect of vitamin d treatment on interleukin-2 and interleukin-4 genes expression in multiple sclerosis
نویسندگان
چکیده
introduction: multiple sclerosis is a chronic inflammatory disease of central nervous system. the etiology of ms is slightly known, but genetic and environmental factors are reported. vitamin d regulates gene expression and affects target cell functions. the aim of this study was to investigate the expression variation of il-2 and il-4 genes under vitamin d supplementation in patients with multiple sclerosis. materials and methods: in this study, blood samples were drawn from 32 patients before and after treatment with vitamin d. quantitative real time pcr was used to measure il-2 and il-4 gene expression levels. correlation analysis between the expression levels of genes and serum vitamin d, the expanded disability status scale (edss) as well as other clinical features of patients with ms was performed. results: no significant difference of il-2 and il-4 genes expression level was observed with vitamin d supplementation. we did not find significant correlation between il-2 and il-4 mrna levels and edss score in multiple sclerosis patients. conclusion: we did not find any difference between the expression of il-2 and il-4 genes before and after treatment with vitamin d that it may have some effects on the prevention of multiple sclerosis through other inflammatory factors and signaling pathways.
منابع مشابه
Effect of Vitamin D treatment on Interleukin-2 and Interleukin-4 Genes expression in Multiple Sclerosis
Introduction: Multiple sclerosis is a chronic inflammatory disease of central nervous system. The etiology of MS is slightly known, but genetic and environmental factors are reported. Vitamin D regulates gene expression and affects target cell functions. The aim of this study was to investigate the expression variation of IL-2 and IL-4 genes under vitamin D supplementation in patients with mult...
متن کاملEffect of Vitamin D treatment on Interleukin-2 and Interleukin-4 Genes expression in Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory neurological disease of central nervous system(Goldenberg, 2012). The etiology of MS is slightly understood. Some investigators have indicated that the prevalence of MS is highest where environmental supplies of vitamin D are lowest (Burton et al., 2010). Some have also showed that vitamin D not only prevents MS, but also attenuates disease activity. B...
متن کاملInterleukin-17A and Interleukin-17F mRNA Expressions in Peripheral Blood Mononuclear Cells of Patients with Multiple Sclerosis
Bakground: Multiple sclerosis (MS) is a CD4+ T cell-mediated autoimmune disease affecting the central nervous system (CNS). It was previously believed that Th1 cells were pathogenic T cells in experimental autoimmune encephalomyelitis (EAE). However, the functional role of Th1 cells in EAE has been reconsidered upon the discovery of IL-17- producing T cells which are consider as dominant effect...
متن کاملToll Like Receptor 2 and 4 Expression in Peripheral Blood Mononuclear Cells of Multiple Sclerosis Patients
Background: Multiple sclerosis (MS) is a T cell mediated autoimmune disease with unknown etiology. Appropriate MS therapeutic strategies need thorough understanding of both disease etiology and pathogenesis mechanisms. Ligation of TLR-2 and TLR-4 stimulates the production of several cytokines leading to CNS autoimmunity and neurodegenerative diseases. Objective: To find a relationship between M...
متن کاملCorrelation of interleukin-2 and soluble interleukin-2 receptor with clinical activity of multiple sclerosis.
Concentrations of interleukin-2 (IL-2) and soluble IL-2 receptor (sIL-2R) in serum and CSF samples were measured in 63 patients with multiple sclerosis (MS) to evaluate their usefulness as markers of disease activity. CSF concentrations of IL-2 and sIL-2R were significantly higher in MS relapse compared with MS patients in remission or with control subjects. These concentrations correlated with...
متن کاملvitamin d and multiple sclerosis.
multiple sclerosis (ms) is a chronic demyelinating disease and also is one of the most common disabling neurological disorders in young and middle-aged adults. the main pathogenesis of ms has long been thought to be an immune mediated disorder of the central nervous system. the function of the immune system is under the influence of vitamin d which as a modulator of immune response could play a...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
physiology and pharmacologyجلد ۱۹، شماره ۱، صفحات ۱۴-۲۱
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023